Synthesis and biological activity of quaternary ammoniopropenyl cephalosporins having two vinyl groups.

During the last decades, the antibacterial activity of cephalosporins has been steadily increased through sidechain modifications at C-3 and C-7. Recently, 3-vinyl cephalosporins, such as TOC-391), E-10772,3) and YM402204,5), have been intensively studied. They show well-balanced antibacterial activity against Gram-positive bacteria including S. aureus and Gram-negative bacteria including P. aeruginosa. Thus we were interested in the synthesis of quaternary ammoniopropenyl cephalosporins having two vinyl groups at C-3 side chain. In this paper, we report the synthesis and biological activity of these novel cephalosporins.